Theanine (pronounced /ˌtea-anene/) (gamma-glutamylethylamide, or 5-N-ethyl-glutamine) is an glutamic acid analog or amino acid derivative commonly found in tea (infusions of Camellia sinensis), and also in the basidiomycete mushroom Boletus badius. In 1950 the Tea laboratory of Kyoto successfully separated theanine from Gyokuro leaf, which has the highest theanine content among all teas. Theanine is an analog to glutamine and glutamate, and can cross the blood-brain barrier. It is sold in the US as a dietary supplement and is FDA confirmed as GRAS. The Japanese Ministry of Health and Welfare approved the use of L-theanine in 1964